URL: https://web.expasy.org/cellosaurus/CVCL_0440
Proper Citation: (AddexBio Cat# T0016002/4922, RRID:CVCL_0440)
Description: Cell line MRC-5 is a Finite cell line with a species of origin Homo sapiens
Sex: Male
Defining Citation: PMID:113411, PMID:211143, PMID:932048, PMID:1031681, PMID:1965304, PMID:3335022, PMID:4316953, PMID:6538202, PMID:7065527, PMID:10752125, PMID:17395773, PMID:19657000, PMID:21637780, PMID:25903999, PMID:26477663, PMID:31869419, PMID:33389257
Comments: Derived from sampling site: Fetal lung. Cell type=Fibroblast., Misspelling: MCR-5; Occasionally., Omics: Transcriptome analysis., Omics: Proteome analysis by 2D-DE/MS., Omics: Proteome analysis by 2D-DE., Omics: Glycosphingolipids analysis., Omics: DNA methylation analysis., Omics: Deep RNAseq analysis., Doubling time: 36 hours (lot 041392), ~5 days (lot 031098), ~2 days (lot 05192003), ~1.5 days (lot 05202005), ~34 hours (lot 06022011), ~38 hours (lot 04212016) (JCRB)., Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Senescence: Capable of attaining 42-46 population doublings before the onset of senescence (ATCC). Senesces at 26 PDL (PubMed=17395773)., Biotechnology: Used for the production of the live zoster vaccine (Trade name: Zostavax)., Biotechnology: Used for the production of the live varicella virus vaccine (Trade name: Varivax)., Biotechnology: Used for the production of the Hepatitis A vaccines Avaxim, Epaxal, Havrix and Vaqta., Biotechnology: Used for the production of the Human Diploid Cell Vaccine (HDCV) against rabies (Trade name: Imovax Rabies)., Group: Vaccine production cell line., Discontinued: CLS; 300395; true., Discontinued: ECACC; 97112601; true.
Category: Finite cell line
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Discontinued
Discontinued: ECACC; 97112601
Source: Cellosaurus
