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Th Th Prkcg Prkcg Fos Fos morphine morphine Pomc Pomc Oprm1 Oprm1 Pdyn Pdyn Cnr1 Cnr1 Oprk1 Oprk1 Oprl1 Oprl1 Oprd1 Oprd1
"morphine" - The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem] in Rattus norvegicus
This is the confidence view. Stronger associations are represented by thicker lines.
Protein-protein interactions are shown in grey, chemical-protein interactions in green and interactions between chemicals in red.
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Edge Confidence
low confidence edge
low (0.150)
high confidence edge
high (0.700)
medium confidence edge
medium (0.400)
highest confidence edge
highest (0.900)
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Score
morphineThe principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem] (285.3 g/mol)    
Predicted Functional Partners:
Oprm1
Mu-type opioid receptor (398 aa)
0.999
Oprk1
Kappa-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions (380 aa)
0.999
Oprd1
Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins (372 aa)
0.999
Th
Tyrosine 3-monooxygenase ; Plays an important role in the physiology of adrenergic neurons (498 aa)
0.995
Fos
Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] (380 aa)
0.992
Cnr1
Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current (473 aa)
0.990
Pomc
pro-opiomelanocortin precursor ; ACTH stimulates the adrenal glands to release cortisol (235 aa)
0.989
Pdyn
proenkephalin-B preproprotein ; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) (248 aa)
0.979
Prkcg
Protein kinase C gamma type ; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (697 aa)
0.979
Oprl1
Nociceptin receptor ; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (367 aa)
0.977
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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