Guenther focuses on subtle interactions between land surfaces and the atmosphere. Much of his research deals with plant emissions of chemicals, such as volatile organic compounds, that can affect local air quality and climate. Guenther is the principal investigator on BEACHON, which examines such issues as whether the destruction of Rocky Mountain forests by pine beetles and other causes can alter local precipitation patters and increase levels of ground-level ozone. Guenther collaborates with the Environmental Protection Agency on research that looks into the impact of future warming temperatures on ground-level ozone and other types of air quality. He is a researcher in NCAR's Atmospheric Chemistry Division.